Basis for revised IDLH: The revised IDLH for parathion is 10 mg/m 3 based on chronic inhalation toxicity data in humans [CDC 1956]. ( 1 ) A reduced number of offspring and decreased fetal weight have been reported in rats exposed to parathion by injection, but no malformations were observed. Effects of methyl parathion (o,o-dimethyl o-4-nitrophenyl phosphorothioate) on rat sperm morphology and sperm count, but not fertility, are associated with decreased ascorbic acid level in the testis. Scientists have been studying the effects of radiation for over 100 years; so we know quite a bit about how radiation interacts with living tissue, and its effect on the body. The successive dosages, which were fed daily as corn oil dilutions by capsule, were 0.003, 0.010, 0.025, and 0.050 mg/kg. In addition to direct toxic effects, it is suspected that insecticidal application has deleterious physical effects on persons with respiratory diseases. It is highly toxic to non-target organisms, including humans, so its use has been banned or restricted in most countries. Parathion undergoes enzymatic oxidation by hepatic cytochrome P-450 (CYP450) enzymes to the active metabolite paraoxon. Call your doctor for medical advice about side effects. In the present work the action of parathion‐methyl and its immediate metabolite paraoxon‐methyl on DNA in human lymphocytes was compared using the comet assay. If people are exposed to levels of methyl parathion below those that affect nerve function, few or no health problems seem to occur. Knowledge on chronic effects of methyl parathion on humans is limited. Environmental pollutants parathion, bisphenol A and paraquat were not systematically studied towards the effects on the expression of phase I xenobiotics-metabolizing cytochromes P450 (CYPs). In this investigation the reactivation of cholinesterases by pralidoxime in parathion and paraoxon intoxication in plasma and erythrocytes were studied. (1,3) Acute exposure by inhalation of methyl bromide frequently leads to neurological effects in humans. No information is available on reproductive effects of parathion in humans; however, methyl parathion, a closely related compound, has been linked with human birth defects. Other pertinent literature is also presented, but is described in less detail than the key studies. Since October 2003, production, importation, or application of parathion in the US is illegal. There has been much lay and medical concern regarding toxic effects of insecticides on the general population. the usage of methyl parathion. There is no evidence that methyl parathion causes birth defects in humans. Acute Effects: Studies in humans indicate that the lung may be most severely injured by the acute inhalation exposure of methyl bromide. Parathion effects on protein synthesis in the seminiferous tubules of mice We conducted a study in Lorain County, Ohio, during the Superfund cleanup All of these effects may not be documented for parathion, but could potentially occur in individual cases. PARATHION-METHYL JMPR 1975 Explanation Parathion-methyl was evaluated by the Joint Meeting in 1968 (FAO/WHO, 1969) and in 1972 (FAO/WHO, 1973). Carol Rubin, Emilio Esteban, Stephanie Kieszak, Robert H Hill Jr, Boadie Dunlop, Rebecca Yacovac, Janine Trottier, Kathy Boylan, Terri Tomasewski, and ; Ken Pearce Therefore, people who use pesticides or regularly come in contact with them must understand the relative toxicity, potential health effects, and preventative measures to reduce exposure to the products they use. Four male and four female volunteer subjects in good health were fed four levels of parathion for 12 weeks at 3 weeks per level. 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