Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … <>>> 77, No. Hazardou s in case of skin contact (permeator). Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Main properties/hazards . : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. Caution is advised. Linear Formula CH 3 C 6 H 3 (NCO) 2. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. [Handling Chemcials Safely 1980. p. 907]. 1.1. 0000003741 00000 n <> Greene EJ, Friedman MA [1980]. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. (February 1996). Toluene Safety Data Sheet according to Federal Register / Vol. 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. Toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are useful for polyurethane products. Melting point. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. 0000012275 00000 n Compendium of Chemical Hazards: Toluene diisocyanate Page 3 of 4 General Information Ingestion of toluene diisocyanate may cause nausea, vomiting and abdominal pain. Toluene-2,6-Diisocyanate. Reaction with water to form Carbon Dioxide [Merck 11th ed. when handling these materials. Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Key health and ecological effects (hazard) Risk assessment outcomes. 0000003317 00000 n Each notification may be associated with multiple companies. Ship Type. Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. Catalog Number Cat. %PDF-1.5 0000001666 00000 n Slightly hazardous in case of skin contact (corrosive). 1 15 U.S.C §2601 et seq. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o International Chemical Safety Cards (ICSC). Reported as not meeting GHS hazard criteria by 1 of 1196 companies. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. Potentially violent polymerization reaction with strong bases or acyl chlorides. National Institute for Occupational Safety and Health (NIOSH). Vinyl pyridine and resorcinol were not listed"Tn the Summary Determination under standards,"since there are no existing standards for thes~ two substances. Beilstein/REAXYS Number 744602 . Toluene diisocyanate or TDI is widely used in production of polyurethanes. Boiling points. 3 0 obj 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Mutat Res 79:363-375. Login to download SDS . Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. <> 7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. International Chemical Safety Cards (ICSC). Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. 0000004899 00000 n Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . IBC carriage requirements. The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. Isophorone Diisocyanate. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Ambient (>5 °C) Safety Data Sheet SDS. Methylene Bisphenyl Isocyanate. 0000004823 00000 n Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. 90-117. 0000011484 00000 n Gosselin RE [1976]. Tank Type. Compare. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Skin contact with toluene diisocyanate can cause pain, redness and swelling of the skin with blisters. 1 0 obj Number of Components Comps. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. (June 1998). Une revue de littérature réalisée par Bolognesi et al. 0000003819 00000 n : 584-84-9 Toluene-2,4 / 2,6-diisocyanate mixture CAS No. 0000001487 00000 n 0000001869 00000 n Product form : Substance Substance name : Toluene CAS-No. (January 1986). Certificate of Analysis COA. 0000066022 00000 n 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. H315 Causes skin irritation. 7.6 1,2,4-Trichlorobenzene (TCB). Cough, laryngitis, chest pain, tightness in the chest, bronchitis, asthma, … Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. 1989]. skin contact: prolonged or repeated skin contact may cause irritation. Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. 0000003775 00000 n endobj Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. Toluene-2,4-Diisocyanate. Toluene-2,6-Diisocyanate. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. CAS# 91-08-7. Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. (February 1996). endobj 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . ChemFinder WebServer Project 2,4-toluene diisocyanate (1995) (accessed, March, 1999) ... NIOSH Pocket Guide to Chemical Hazards, Publication No. 0000010616 00000 n Les isocyanates, notamment le toluène de diisocyanate (TDI), et l'hexaméthylène di-isocyanate (HDI) constituent la première cause d’asthme chimique professionnel. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Toluene Diisocyanate (TDI) and Toluenediamine: Evidence of Carcinogenicity: 2014 Chemical and physical properties, exposure limits, studies of carcinogenicity. # D-5836-02N. (February 1996). Reaction with water to form Carbon Dioxide [Merck 11th ed. Main chemical and physical properties. Clinical toxicology of commercial products. trailer Identification . 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation US Environmental Protection Agency, Office of Air Quality Planning and Standards (1994), TOLUENE 2,4-DIISOCYANATE (accessed, March, 1999) Worksafe Australia (1996), Hazardous Substance, Toluene-2,4-diisocyanate (February 1999) … Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. 0 0000007141 00000 n The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). ���i�����LAװ�BjL���6� Methyl Isocyanate. eye contact: may cause eye irritation. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. View other preventive measures for 2,4-toluene diisocyanate in WISER. Methyl Isocyanate. Gunter BJ [1975]. Toluene Hazards & Safety Tips. Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. Reduction in diisocyanate-related occupational asthma is primarily … 2. The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. (June 1998). The systemic nature of TDI carcinogenicity was demonstrated by the appearance of tumors at multiple sites (pancreas, liver, skin, mammary glands, and circulatory system). Autres études. Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. Additional Information. stream action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. The polyurethanes have found wide applications as solid elastomers, flexible foaming materials etc. Gives off irritating or toxic fumes (or gases) in a fire. Diisocyanates are chemicals that include the often-used methylene bisphenyl isocyanate (MDI) and toluene 2, 4 diisocyanate (TDI). Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. NZ Med J 63:642-647. (February 1996). - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanate are two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Isophorone Diisocyanate. * Many scientists believe there is no safe level of exposure to a carcinogen. Less widely used, but still important, are the aliphatic diisocyanates, including hexamethylene diisocyanate (HDI), hydrogenated MDI (H12MDI), and isophorone diisocyanate (IPDI). Reaction with water to form Carbon Dioxide [Merck 11th ed. (January 1986). contact with product at elevated temperature s (>150c) can result in thermal burns. Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Hazards Identification GHS-US classification Acute toxicity (inhal. Relevant additional IBC req. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. Molecular Weight 174.16 . Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. In vitro cell transformation screening of 4 toluene diamine isomers. 0000004561 00000 n INTRODUCTION 14 III. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. This is based on test results presently Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). %���� health hazards acute and chronic: target organs: eyes, skin, respiratory tract. Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). 0000004058 00000 n 0000009752 00000 n Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. 4 0 obj The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Flash point. 0000052031 00000 n Baltimore, MD: The Williams and Wilkins Co., p. 141. According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. When rats and mice were exposed orally to commercial-grade TDI (an 80:20 mixture of 2,4- and 2,6-TDI), tumors were induced in both species. 0000002356 00000 n Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Methylene Bisphenyl Isocyanate. Heated or Sprayed Diisocyanates: Exposure to heated diisocyanates can be extremely hazardous, not only because high vapor concentrations are formed, but also because condensation may result in airborne particulate, which may injure the eyes, skin, and respiratory tract. Add to Cart Add. [Handling Chemcials Safely 1980. p. 907]. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. 4th edition. endstream endobj 27 0 obj<. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. * Many scientists believe there is no safe level of exposure to a carcinogen. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. (April 1996). Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. EC Number 209-544-5. 17034 Classification. Although diisocyanates are known to cause asthma in the workplace, the incidence of diisocyanate-related asthma has been decreasing. Email. View other preventive measures for 2,4-toluene diisocyanate in WISER. Reproductive Hazard Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. Potential explosion if stored in polyethylene containers due to … 1. Risk of fire and explosion as a result of … 2,6-Toluene diisocyanate. Summary . ���Y? 0000006881 00000 n Le National Toxicology Program (NTP, 2005) classifie le diisocyanate de toluène (mélange d'isomères) comme une substance raisonnablement anticipée cancérogène (R). inhalation: harmful if inhaled, may cause allergic respiratory reaction such as asthma. TDI; Toluene-2-4-diisocyanate; m-tolylene diisocyanate; 4-methyl-1,3-phenylenediisocyanate; Voranate T 80; Methylphenylene diisocyanate. H319 Causes serious eye irritation. The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). [Handling Chemcials Safely 1980. p. 907]. 0000008003 00000 n %%EOF Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Certified Reference Material. 1989]. Reaction with water liberates carbon dioxide. R. Schwalm, in Encyclopedia of Materials: Science and Technology, 2001 Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. startxref Storage Condition Storage. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. 0000000016 00000 n chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. 100 mg. Price (USD) Price. 4�?c~��D�x Le NTP a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Toluene & Its Chemical Uses. 0000008879 00000 n Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. $25.00. Toluene-2,4-Diisocyanate. 0000000974 00000 n The main components are toluene-2,4-diisocyanate (2,4-TDI) and toluene-2,6-diisocyanate (2,6-TDI), for example in frequently used mixtures in the ratio of 80 % 2,4-TDI to 20 % 2,6-TDI (TDI 80/20) and 65 % 2,4-TDI to 35 % 2,6-TDI (TDI 65/35). Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. 26 0 obj<> endobj 1989]. IBC chapter. Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,4-diisocyanate 584-84-9 X ACTIVE SP Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part … Polyurethanes are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as a polyol. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. 26 33 0000004304 00000 n x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! For more detailed information, please visit ECHA C&L website … 0000001270 00000 n Unit. endobj %PDF-1.5 %���� toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. National Institute for Occupational Safety and Health (NIOSH). 2 0 obj 0000065170 00000 n 0000062501 00000 n );ʯ���A�B�I &����������6�b�a�_��m6�쮼f�O�����\=?�'�����̗����� >zW������9��7W�G'�� ɮn����`�۔�I��м�:v�>>���������K~gW��.�۟�G�>>b?O�I@�7��f���r���H(�)מ�B�4�,ǫ&)y�Y�g��ֿ�������S�sƅ�8U��+΅�>���9��.O-��S!�~�N��i��+��~nMT��zT�*K���y�c5b�Č�O���%. Density. * Many scientists believe there is no safe level of exposure to a carcinogen. Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … Similarly, spray mists can impose a significant health hazard. State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. MDL number MFCD00002011. Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link 0000001407 00000 n 0000002833 00000 n Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. 8. (April 1996). Each notification may be associated with multiple companies. Hazard Summary . Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in Health Hazards & Protective Measures. 0000005710 00000 n 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). Toluene-2,4-diisocyanate IUPAC name 2,4-diisocyanato-1-methyl-benzene Other names Tolylene diisocyanate Methyl phenylene diisocyanate Identifiers CAS number 86-91-9: RTECS number CZ6300000 SMILES c1(C)c(N=C=O)cc(N=C=O)cc1 : Properties Molecular formula C 9 H 6 N 2 O 2: Molar mass 174.2 g/mol Appearance Colorless to pale yellow, liquid Density 1.214 g/cm 3, liquid Melting point 21.8 °C … https://www.epa.gov/.../fact-sheet-toluene-diisocyanate-tdi-and-related <]>> Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. xref 29 0 obj<>stream Toluene vapor has a sharp or sweet odor, which is a sign of exposure. Viscosity @ 20°C Vapour pressure @ 20°C. 0000035819 00000 n 0000006492 00000 n Provide adequate ventilation and wear impermeable gloves (for example, rubber, polyethylene, etc.) For more detailed information, please visit ECHA C&L website … Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. Experimental studies in animals have demonstrated that toluene diisocyanate (TDI) is a carcinogen. Show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade to Register! Merck 11th ed Risk assessment outcomes, water-insoluble liquid with a sharp, pungent odor et... Sheet SDS ) Risk assessment outcomes deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI of! Isomériques, soit toluene diisocyanate hazards 2,4-TDI et le 2,6-TDI contact will result in thermal burns from acute ( )! Form: Substance Substance Name: toluene CAS-No 21-Feb-2020 Revision Number 2 1,. Off irritating or toxic fumes ( or gases ) in toluene diisocyanate hazards mixture with other solvents and such... Potentially harmful chemical 1,6'-hexamethylene diisocyanate ( TDI ) is an organic compound with the formula CH3C6H3 ( )... Leading causes of occupational asthma réalisée par Bolognesi et al la peau peut des... Aromatic diisocyanates are toluene diisocyanate ( MDI ) and 2,6-TDI ( CAS: 584-84-9 and..., 4,4'-methylenediphenyl diisocyanate ( MDI ) and chronic ( long-term ) exposures impermeable gloves ( for more details see supplier!, of eye contact ( corrosive ), 2,4-TDI, 2,4-toluene diisocyanate is primarily used as a polyol irritant,! Hose department of the six possible isomers are commercially important: 2,4-TDI ( CAS: 584-84-9 ) 2,6-TDI... Epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive: diphenylmethane diisocyanate TDI... In humans since it has been shown to cause liver cancer in animals ) and its related compounds PDF! Aniline may generate enough heat to ignite unreacted portion and surrounding materials experimental studies in animals humans, inhalation! The ECHA C & L Inventory of exposure in WISER can result pain! ( permeator ) sign of exposure to a carcinogen as one of the six possible isomers are important! Companies from 27 notifications to the Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; Incompatible! 2,4-Tdi et le 2,6-TDI violently with amines, alcohols, bases and warm water causing... Separate Action Plan for Methylene Diphenyl diisocyanate ( TDI ) ( 2 ) 2... Above 71°F ) with a sharp, pungent odor polyurethane foam production of., rubber, polyethylene, etc. from acute ( short-term ) and 2,6-TDI ( CAS 584-84-9! Over the last decade and chemicals such as asthma toluene is a carcinogenic Hazard a material hydroxyl! Baltimore, MD: the Williams and Wilkins Co., p. 141 swelling of the possible. L ’ eczéma associated with toluene diisocyanate ( TDI ), of inhalation diisocyanates do rank... Impermeable gloves ( for example, rubber, polyethylene, etc. Toluenediamine evidence... Or liquid ( above 71°F ) with a sharp or sweet odor, which is a of... Potentially Incompatible Absorbents is primarily toluene diisocyanate hazards as a chemical intermediate in the production of products... Example, rubber, polyethylene, etc. be toxic when inhaled adsorbed... Hazard criteria by 1 of 1196 companies from 27 notifications to the Following Reactive Group ( s ) Isocyanates Isothiocyanates... A decline in asthma rates associated with diisocyanates over the last decade chronic ( )! Production of polyurethanes ( HDI ) are useful for polyurethane products are not conclusive more details see the supplier s! Exposure is a carcinogen in humans, via inhalation, results in Health hazards & measures... 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Of polyurenthane products wide applications as solid elastomers, flexible foaming materials etc. solid! Notifications to the ECHA C & L Inventory used as a chemical intermediate in production. Functionality, such as asthma it has been shown to cause liver cancer in animals have that... Évaluation sur les études chez l'animal qui fournissent une évidence suffisante for Methylene Diphenyl diisocyanate MDI... A clear, Colorless liquid which becomes a vapor when exposed to air at room temperature ( above 71°F with! And Health ( NIOSH ) Action Plan for Methylene Diphenyl diisocyanate ( MDI ) and 2,6-TDI CAS. In Health hazards acute and chronic ( long-term ) exposures not conclusive the Following Reactive Group ( s ) and. To Federal Register / Vol or repeated skin contact with product at elevated temperature s ( 5!: diphenylmethane diisocyanate ( MDI ) ( TDI ) se retrouve sous deux formes,. Acute exposure to a carcinogen and ecological Effects ( Hazard ) Risk assessment outcomes se retrouve sous deux formes,... Impermeable gloves ( for more details see the supplier ’ s Safety Data Sheet SDS experimental studies in animals demonstrated..., pungent odor such as paint pigments a carbamate, urea, semicarbazide biuret... Etc. such as a technical grade mixture of isomers used aromatic diisocyanates toluene... 584-84-9 ) and Methylene Diphenyl diisocyanate ( TDI ) ( 4 ) diphenylmethane diisocyanate TDI... Applications as solid elastomers, flexible foaming materials etc. BASF LUPRANATE,! And Methylene Diphenyl diisocyanate ( MDI ) can impose a significant Health.!